ADAM12 and small cell lung carcinoma: The ROC curves yielded a higher AUC of 0.899 (P<0.001, 95% CI: 0.842 to 0.956) for 346 pg/ml in serum ADAM-12 level from SCLC patients (Figure 3B) than normal controls (a AUC of 0.847 for 105 pg/ml), and a higher AUC of 0.979 (P<0.001, 95% CI: 0.959 to 0.999) for 258 pg/ml in urine ADAM-12 level from SCLC patients (Figure 3C) than normal controls (a AUC of 0.869 for 92 pg/ml).