The anti-colitis effect of L. salivarius 33 was correlated with the expansion of CD4+Foxp3+ T cells in the MLN [46] while VSL#3 increased the population of Tregs bearing surface TGF-beta in the form of latency-associated protein (LAP) (LAP+ T cells) in the lamina propria [14]. Here, CD4 is linked to colitis.