Patients with Crohn's disease having specific polymorphisms in NOD2 are more likely to have an earlier onset of disease, ileal involvement, fibrostenosis and an increased likelihood for ileocecal surgery.[4] In IF patients, the NOD2 polymorphism rs2066844 was more frequent in patients with short gut syndrome that required a combined liver-intestine transplant [5] and in those patients who had graft rejection post intestine transplantation [6]. Here, NOD2 is linked to Crohn disease.