We next examined whether there were any differences in the frequency of the polymorphisms of NOD2, CARD9, RAC1 and ATG16L1 in relation to major clinical outcomes (conjugated hyperbilirubinemia, sepsis episodes, use of parenteral nutrition for >1 year and need for transplantation) among the 59 children with IF. This evidence concerns the gene CARD9 and Hyperbilirubinemia.