NOD2 and hereditary disease: In fact, the study of genomics and stem cell biology in medicine is increasingly directed toward individualized care for subpopulations of patients with specific genetic disease pathology, phenotype or disease complications in an effort to understand the pathophysiology and potentially offer diagnostic as well as therapeutic tools earlier in the disease evolution.[2], [3] Among other examples are studies related to NOD2 (nucleotide-binding oligomerization domain-containing protein 2), an intracellular microbial sensor that plays a role in intestinal immune homeostasis.