NOD2 and Crohn disease: The ATG16L1 interacts with NOD2 in a signaling cascade that leads to autophagy of bacterial fragments and antigen presentation by dendritic cells.[8] We also did not observe a higher frequency of the high risk NOD2 alleles reported in Crohn's disease (SNPs: rs2066844, rs2066845, rs2066847) in our population as compared to healthy adult controls and as risk alleles for IF complications.