RB1 and breast cancer: Among the shared alterations, we identified five core MRAs shared by all samples (Figure 5E) – gains on 17q and 8q and losses on chromosomes 6, 12 and 13 – harboring multiple oncogenes and tumor suppressor genes, i.e. MYC, MTDH, RB1 and CDKN2A, that were previously associated with the progression of breast cancer [32], [33].