SFRP5 and type 2 diabetes mellitus: In contrast, two other studies on Asians showed decreased circulating Sfrp5 levels in patients with T2D versus subjects with normal glucose tolerance, and reported a negative association between plasma levels of Sfrp5 and HOMA-IR (r = −0.446, p<0.01) [12] and (r = −0.444, p<0.001) [11].