The results of this economic analysis on early KRAS testing in CRC patients, including those at high as well those at very low risk, show that the incremental cost-effectiveness ratio remains within the range of 6,000 to 15,000 Euro per quality adjusted life year (QALY) gained, regardless of the level of risk of developing metastases and far within the threshold of 60,000 Euro/QALY gained accepted by regulatory institutions in Italy (Table 3). This evidence concerns the gene KRAS and colorectal carcinoma.