KRAS and metastatic neoplasm: In order to simulate the incremental cost effectiveness that would be generated by early KRAS testing in high risk patients and to test the robustness of results, we conducted several analyses under different assumptions, by setting the level of risk of developing metastatic disease at the level of 1 patients out of 2 (i.e. 50% chance), 1/3, 1/4, 1/5 and 1/10, i.e. including very low risk.