Nevertheless, in addition to directly affecting memory-related processes, the various impacts of Aβ oligomers on neurons might have the potential to account for major facets of AD neuropathology (for example, tau hyperphosphorylation, glial activation and synapse loss) supporting the concept that Aβ oligomers provide a unifying mechanism for initiation of AD pathogenesis. Here, MAPT is linked to Alzheimer disease.