The genetic evidence from retroviral insertional mutagenesis studies and the CD2-Lmo2 and human T-ALL gene expression clustering result could be explained if Hhex was a direct target of Lmo2. Thus, we mined existing anti-Ldb1 ChIP-seq datasets from Lineage− HSPCs for enrichment of sequences near Hhex[35]. Here, LDB1 is linked to acute lymphoblastic leukemia.