Among them is the very small sample size derived over a 3-month period of time; review of medical records that despite our hierarchal strength-of-evidence approach had limited documentation of HIV-serology; other laboratory tests indicative of HIV infection were scant, which precluded any correlation of immunodeficiency (level of CD4+ count) with type of cancer diagnosis; and no documentation of plasma HIV-1 RNA levels. The gene discussed is CD4; the disease is immunodeficiency disease.