In the acute phase of stroke activation of cytokines [interleukin-1 beta (IL-1ß), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α)] [5], chemokines [monocyte chemostatic protein-1 (MCP-1) and macrophage inflammatory protein-1 alpha], [6] matrix metalloproteinases (MMPs) [7], adhesion molecules ICAM-1, P-selectin, E-electin and toxic molecules such as nitric oxide, free radicals, apoptosis (Caspase 3), and stress genes (hsp 70 and hsp 32) occurs. Here, TNF is linked to Stroke.