Similarly, glioblastoma tissue showed increased DEspR-positive expression in tumor cells and microvascular endothelium, and co-localized with CD133, a marker for GBM-CSCs [31], thus suggesting DEspR+/CD133+ putative CSCs close to microvessels (Figure 2C), consistent with the microvascular-CSC niche paradigm [17], [18]. This evidence concerns the gene PROM1 and glioblastoma.