FBXW7-AS1 and cancer: DEspR roles in cancer are deduced from its embryonic-lethal null mutation phenotype resulting in E10.5–12.5 day embryonic lethality characterized by abnormal vasculogenesis with incomplete dorsal aorta formation, and by absent angiogenesis, and failed endocardial-to-mesenchymal transition/migration resulting in thin-walled hearts [22].