To define DEspR functional roles in tumor angiogenesis, we demonstrate that DEspR is increased in tube-forming angiogenic HUVECs but not in quiescent HUVECs (Figure 3A), and that anti-DEspR (7c5b2)-inhibition decreased angiogenic tube length and branch formation (Figure 3C) in a dose-response manner (Figure 3C) in HUVECs grown in angiogenic culture conditions. Here, FBXW7-AS1 is linked to neoplasm.