FBXW7-AS1 and neoplasm: This predicted positive feedback loop between DEspR-activated Akt, Src, FAK, STAT 3 and HIF-1alpha activation suggests the hypothesis that DEspR activation can contribute to the observed constitutive activation of these established pro-malignancy signaling networks [44], [45], [53]–[58] even after tumor hypoxia is decreased or resolved.