Since the multifunctionality of VEGFsp beyond targeting of the VEGF propeptide to the endoplasmic reticulum is apparent given specific binding of VEGFsp to DEspR [22], [31] and stimulation of VEGFsp-DEspR-specific signaling (Figure 1B), we studied DEspR-VEGFsp co-localization in human umbilical vein endothelial cells (HUVECs) and pancreatic cancer Panc1 cells. This evidence concerns the gene VEGFA and pancreatic neoplasm.