As shown in Figure 5A, anti-DEspR treatment (both anti-rat and anti-human DEspR inhibition) decreased Panc1-CSC xenograft nude-rat tumor growth compared to non-treated controls, P<0.01, in contrast to gemcitabine failure using standard human doses of gemcitabine (Figure 5B). The gene discussed is FBXW7-AS1; the disease is neoplasm.