DU 145 or DU 145-vector cells formed no tumor when injected into mice tibiae while DU 145-PTHrP(1–141) or DU 145-PTHrP(1–173) cells injected into mice tibiae resulted in tumor formation, invasion and destruction of bone (Figure 5), confirming the well established role of PTHrP in bone resorption. Here, PTHLH is linked to neoplasm.