PTHLH and cancer: PTHrP is known to activate a variety of mitogenic pathways including MAPK and PI3K/Akt as well as pathways that stimulate skeletal metastases, one of the most common life-threatening disorders associated with cancer [4]–[6].Secreted PTHrP is known to mediate its cellular effects via interaction with the G-protein-coupled PTH/PTHrP receptor [7].