Since curcumin has been described to reduce the invasion of several types of cancer partly via inhibition of matrix metalloproteases [46]–[49], to avoid the confounding effects of curcumin on proteolitic enzymes, we tested if overexpression of cortactin and/or curcumin can modify HCT116, SW480, and HT29 colon cancer cell migration through uncoated semi-permeable membranes, as described in Materials and Methods. Here, CTTN is linked to malignant colon neoplasm.