Some studies have reported that ghrelin confers a variety of potentially beneficial cardiovascular effects, which include reducing blood pressure, increasing cardiac contractility, protecting endothelial cells, improving myocardial energy metabolism, regulating atherosclerosis, preventing ischemia/reperfusion injury, and improving the prognoses of myocardial infarction (MI) and HF [19]–[22]. Here, GHRL is linked to atherosclerosis.