As shown in Figure 3A, there was a notable increase in plasma IL-22 from T2D patients (median, 47.56 pg/mL; range, 30.55–76.89 pg/mL) as compared with MHO patients (median, 36.65 pg/mL; range, 29.52–55.70 pg/mL; *P<0.0001) and CTLs (median, 36.33 pg/mL; range, 31.93–40.62 pg/mL; n = 16; *P<0.0001). This evidence concerns the gene IL22 and type 2 diabetes mellitus.