NPAS4 and neurodegenerative disease: Given NPAS4 is activated following neuronal activity to control the balance of excitatory and inhibitory synapses, and that defects in memory, social anxiety, age related neurodegeneration, hyperactivity and seizures are observed in NPAS4 null mice, NPAS4 has been implicated in a number of neuropsychiatric and neurodegenerative diseases [15], [16], [29], [32].