The proteins PKM2 (pyruvate kinase isozyme M2), YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide), and PRDX2 (peroxiredoxin 2) were located in the most central area of the network, followed by PSMA6 (proteasome subunit alpha type 6), KRT18 (keratin 18), ACTB (beta-actin), PGK1 (phosphoglycerate kinase 1), TPI1 (triosephosphate isomerase 1), HSPB1 (heat shock protein beta-1), PARK7 (Parkinson disease (autosomal recessive, early onset) 7), and PSMB3 (proteasome subunit beta type 3). The gene discussed is PKM; the disease is Parkinson disease.