We found that expression of both GRP75 and HSP90 in the HCC tissues were positively correlated with the development and progression of liver cancer,since high levels of GRP75 expression were detected in 30 out of 31 tumors from T3 patients, but in only 11 out of 32 tumors from T2 patients, and high levels of HSP90 expression were detected in 28 out of 31 tumors from T3 patients, but in only 9 out 32 tumors T2 patients. Here, HSPA9 is linked to liver cancer.