The NPR3 SNP rs2270915 has been shown in 3,126 subjects of the Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) trial to be associated with hypertension in diabetics and was validated by replication in an additional 2,452 diabetic, hypertensive patients [16]. This evidence concerns the gene NPR3 and hypertensive disorder.