Genetic variation in NPPA, the gene encoding the precursor of atrial natriuretic peptide (ANP) also appears to be associated with a variable response to anti-hypertensive therapy wherein C allele carriers of NPPA T2238C have less cardiovascular and stroke events and lower blood pressures with the use of chlorthalidone as compared to amlodipine or lisinopril [8]. This evidence concerns the gene NPPA and stroke disorder.