PKM and hepatocellular carcinoma: For instance, we have previously shown that miR-122 downregulation potentially affects the development of hepatocellular carcinoma (HCC) by regulating multiple genes associated with processes like apoptosis, cell cycle, cell death, cell differentiation, cell growth, cell proliferation and mitosis, including Vimentin, CREB1, SEPT2, PKM2 and CREB [44].