The CD127lo CCR7−CD45RA−CD8+ T cell or CCR7−CD45RA+CD8+ T cell subsets exhibited negligible expression of IL-2 mRNA, whereas the average expression level of IL-2 mRNA was 100- fold higher in the OSCC groups, and 4- fold higher in the HD group in CD127hi CCR7−CD45RA−CD8+ T cell or CCR7−CD45RA+CD8+ T cell subsets upon anti-CD3 and anti-CD28 stimulation. Here, CD8A is linked to Huntington disease.