Interestingly, a negative correlation was found in the distribution percentage between CCR7−CD45RA−CD8+ T cell and CCR7−CD45RA+CD8+ T cell subsets in OSCC patients (Fig. 1C), suggesting that dynamic changes in circulating CCR7−CD45RA+CD8+ T cell and CCR7−CD45RA−CD8+ T cell occurred during cancer progression. The gene discussed is CD8A; the disease is cancer.