Notably, the CCR7−CD45RA−CD8+ T cell and CCR7−CD45RA+CD8+ T cell are also found to be the major CD8+ subsets in tumor infiltrating lymphocytes with a significantly higher amount of CCR7−CD45RA−CD8+ T cell than CCR7−CD45RA+CD8+ T cell (Fig. 2C). This evidence concerns the gene CD8A and neoplasm.