HSPB1 and neoplasm: As previously reported [11], we determined that HSPB1 is highly expressed and secreted in tumor vascular ECs derived from primary sarcoma and lung adenocarcinoma mouse models (K-rasLSL-G12D/WT; p53Flox/Flox) compared to tumor cells (Figure 1A, B and Figure S2 in File S1).