Biotin-ATN-658 did not bind to mouse melanoma (B16) cells (Fig. 1A) or African green monkey (AGM) (Fig. 1B) immortalized kidney cells (COS-1) in whole cell saturation binding experiments, whereas saturable binding was observed to the uPAR expressing human prostate cancer cell line, PC-3 (Fig. 1A&B), as previously described [27]. Here, TYR is linked to prostate cancer.