Sixteen different FA genes have now been identified whose products act in a common pathway of DNA interstrand crosslink repair, and some of them (including BRCA2/FANCD1, BRIP1/FANCJ, PALB2/FANCN, and RAD51C/FANCO) have also been described as breast and ovarian cancer susceptibility genes [9], [10]. The gene discussed is PALB2; the disease is ovarian cancer.