LOX and type 2 diabetes mellitus: It was found that cyclooxygenase-(Cox) derived prostanoids (e.g., prostaglandin E2) as well as 12/15 lipoxygenase (Lox) derived metabolites (e.g., 5-Hydroxyeicosatetraenoic 15-Hydroxyeicosatetraenoic acid) were slightly decreased in type-2 diabetic patients taking anti-hypertensive medication compared to controls.