Although negative feedback factors like suppressor of cytokine signalling 3 (SOCS3) [7] and monocyte chemoattractant 1-induced protein (MCP1-IP) [8] act to suppress pro-inflammatory cytokine signalling, these feedback factors may be dysfunctional in obese humans with type 2 diabetes [9]. This evidence concerns the gene SOCS3 and type 2 diabetes mellitus.