In the first discovery cohort of this meta-analysis consisting of 99 Hong Kong Chinese patients with YOD diagnosed before 40-year-old with at least 1 affected first degree relative and obesity, the T allele of rs1408888 in intron 1 of DACH1 (Dachshund homolog 1) with P<10−5 was replicated in a multiethnic Asian case-control cohort, albeit insignificant in Caucasians. Here, DACH1 is linked to obesity disorder.