PAX4 and obesity due to melanocortin 4 receptor deficiency: Unlike the novel SNP rs10229583 at 7q32 near PAX4 discovered in a meta-analysis of 3 GWAS comprising 684 T2D patients and 955 controls of Southern Han Chinese descent with confirmation in a multi-ethnic population (Pmeta = 2.3×10−10 in East Asians; P  = 8.6×10−3 in Caucasians) [12], the risk association of rs1408888 with T2D was increasingly attenuated in a multi-ethnic population, suggesting that this SNP might be more relevant to Asians undergoing rapid transition characterized by obesity and young age of diagnosis [6].