DACH1 and obesity due to melanocortin 4 receptor deficiency: In an adequately powered case-control cohort of familial YOD characterized by obesity, we discovered several common SNPs (allele frequency>0.3) with ORs of 2–2.5, including the T allele of rs1408888 of DACH1 with allele frequency of 0.75 and an OR of 2.49.