In head and neck squamous cell carcinoma (HNSCC) specifically, several reports indicate 70% to 100% MET overexpression, suggesting that the HGF/MET pathway plays a role in carcinogenesis.[8], [12], [18]–[21]HGF/MET signalling could also interfere with response of oropharyngeal squamous cell carcinoma (OPSCC) to radiotherapy (RT).[22]. This evidence concerns the gene HGF and oropharynx squamous cell carcinoma.