HGF and head and neck squamous cell carcinoma: Later, reports describe that compartment localization of c-Met is linked to differentiation and stage of OPSCC tumors.[19] In one study, HNSCC's and their metastases were analyzed, showing that MET expression was increased from 2- to 50-fold in about 70% of tumors.[37] Kim et al. previously reported that elevated HGF/c-MET expression in HNSCC correlated with tumor progression[40], and later showed that survival was significantly affected in patients with c-MET expression in SCC of the oral tongue[21], [41].