MET and head and neck squamous cell carcinoma: This MET Y1235D mutation and another mutation in the MET activation loop (Y1230C) were also detected in neck lymph nodes metastases from a primary HNSCC tumor.[25] Recently, another epidemiological study reported novel mutations in the SEMA, JM, and TK domains of MET in 13.5% of the cases, and an increased MET gene copy number (>10 copies) in 3 out of 23 cases.[8]