In a pilot study, Druzgal et al. compared pre-treatment and post-treatment cytokine levels in HNSCC, and found evidence for a strong relationship between HGF serum levels and both therapeutic response and survival.[47] Uchida et al. studied HGF/MET in oral SCC and found significantly higher HGF concentrations in metastatic cancer tissues, than non-metastatic or normal tissue. This evidence concerns the gene HGF and metastatic malignant neoplasm.