Moreover, the physical interaction between DENV NS4B and the helicase domain of NS3, a functional complex important for replication [32], was confirmed by biochemical pull-down and immunoprecipitation assays, both with purified proteins and with DENV-infected cell lysates, suggesting that transfected NS4B is functionally similar to wild type counterpart during infection [31]. The gene discussed is KRAS; the disease is infection.