Whereas these results suggested that NKT cells have a limited role or no effect in HFD-induced metabolic disorders [16], [35], two other recent studies using the same mouse model demonstrated NKT cell-deficient mice to have reduced body weight, smaller adipocytes, milder hepatosteatosis, and improved glucose sensitivity and insulin tolerance compared to WT mice following HFD feeding [22], [37]. This evidence concerns the gene INS and Other metabolic disease.