AKT1 and esophageal squamous cell carcinoma: Moreover, NEFH promoter methylation in esophageal squamous cell carcinoma (ESCC) has been functionally linked with loss of expression and activation of the v-akt murine thymoma viral oncogene homolog (AKT)/β-catenin pathway also leading to increased glycolysis rates and changes in mitochondria 27.