NEFH and renal cell adenocarcinoma: Considering that NEFH methylation or altered expression have not been reported for cancers other than ESCC thus far, our findings of hypermethylation taking place both in RCC as a highly malignant tumor and in tumor cell lines from mammary, prostatic, and urothelial cancers further underline the potential relevance of NEFH in carcinogenesis.