In the course of a combined in silico analysis of gene expression and a genome-wide re-expression analysis using the demethylation agent 5-aza-2′-deoxycytidine in renal cancer cell lines we already identified new potential DNA-methylation-based candidate prognosticators for ccRCC 19,20 and also found the Neurofilament Heavy polypeptid (NEFH) CGI as a further epigenetic mark of potential interest. The gene discussed is NEFH; the disease is renal carcinoma.