MECOM and acute myeloid leukemia: EVI1 is a transcriptional regulator with an important function in haematopoiesis and self-renewal.1 Aberrant overexpression of EVI1 has been firmly established as one of the most adverse prognostic markers in acute myeloid leukaemia (AML),2 implying that EVI1 is one of the most aggressive oncogenes in AML.