The variability of EVI1 expression in the MLL-rearranged ALL group might be partly dependent on specific MLL gene rearrangements, as AMLs with MLL/AF6 and MLL/AF9 fusions are associated in particular with high EVI1 expression in adults and children.5, 12 We found no obvious possible cause for variability of EVI1 expression in ALL of other cytogenetic subgroups. This evidence concerns the gene MECOM and acute lymphoblastic leukemia.