It has been shown that MT1-MMP is localized to the leading edge of different migratory and/or invasive cells, including to the lamellipodia (Mori et al., 2002), podosomes (Wiesner et al., 2010), collagen attachment sites (Bravo-Cordero et al., 2007), focal adhesion sites (Wang and McNiven, 2012) and invadopodia of invasive cancer cells (Nakahara et al., 1997; Poincloux et al., 2009). The gene discussed is MMP14; the disease is cancer.