BACE2 and neurodegenerative disease: Holler et al. (2012) reported an increase in BACE2 messenger RNA in DS that did not translate into increased BACE2 protein levels and activities in DS, despite increases in other neurodegenerative diseases. However, overexpression of BACE2 was found to decrease amyloid beta production in neuronal cultures (Abdul-Hay et al., 2012; Sun et al., 2006).