PPP1R3C and breast carcinoma: To the best of our knowledge, validated data on hypoxia-regulation of the four hypoxia-regulated genes exist for PPP1R3C (up-regulated in MCF-7 breast cancer cells) [33] and on MME, which was shown to be up-regulated in primary rat astrocytes [34] and down-regulated in pulmonary artery smooth muscle cells [35], human neuroblastoma cells [34], rat neurons [34], and mouse neurons [36].