PPP1R3C, KCTD11, FAM115C, and HK2, a well-known hypoxia-regulated gene, were up-regulated by hypoxia in a panel of NSCLC cell lines to variable degrees, while MME mRNA showed no increase in expression under hypoxia in any of the cell lines (Figure 3C). This evidence concerns the gene MME and non-small cell lung carcinoma.