Even though type I interferon (IFN-I: IFNα and IFNβ) was identified 30 years ago to be elevated in SLE patient serum, it is only in recent years that its increased expression has been rediscovered and postulated to play a key role in disease pathogenesis in the majority of patients [1-4]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.