COMT and cancer: While the discovery of COMT genetic polymorphisms has illuminated a host of biologic vulnerabilities ranging from cancer to neurobehavioral pathology, recent evidence suggests that epigenetic changes, particularly DNA methylation of CpG (e.g., “C – phosphate - G” on the same DNA strand) dinucleotide sequences in the COMT gene, may also have an important impact on COMT function[52,53].