SLCO1B1 and myopathy: Despite the high attributable risk for the SLCO1B1 rs4149056 polymorphism reported in the SEARCH study, other genetic polymorphisms are likely to contribute to risk of statin-associated myopathy, including rare variants not detected by genome-wide association studies.32,59,60 Overall response will be determined by a combination of multiple genetic and non-genetic factors, including gender, age, racial/ethnic background, BMI, co-morbidities and other medications.