SLCO1B1 and myopathy: The strongest support for an association of statin-induced myopathy with the SLCO1B1 rs4149056 C allele comes from the SEARCH study of patients with prior myocardial infarction who were taking 80 mg simvastatin.8 In a genome-wide association study of 85 patients of European ancestry with “definite” or “incipient” myopathy and 90 matched controls, the C allele was associated with myopathy with an odds ratio of 4.5 per C allele (95% CI 2.6-7.7).