In 2008, a genome-wide association study (the SEARCH Study) found an association between myopathy on high-dose (80 mg) simvastatin and a polymorphism in the SLCO1B1 gene encoding organic anion transporting polypeptide 1 (OATP1B1), a membrane transporter that facilitates hepatic uptake of statins.8 The association was with a non-coding single nucleotide polymorphism (SNP) in SLCO1B1 that is in near-complete linkage disequilibrium with a functional SNP, rs4149056 (c.521T>C). Here, SLCO1B1 is linked to myopathy.