The difference in desmin expression highlights the two distinct pathways of differentiation that these precursor stem cells take, one of which follows a fibroblastic/lipocytic lineage, losing desmin expression, to form a spindle cell lipoma, and the other follows a myofibroblastic lineage, retaining desmin expression, to produce a myofibroblastoma [9]. This evidence concerns the gene DES and spindle cell lipoma.