NFKB1 and Crohn disease: By analyzing the composition of the intestinal microbiota of Crohn’s disease patients, Sokol et al. (21) identified Faecalibacterium prausnitzii, which is greatly reduced in Crohn’s disease patients, as an anti-inflammatory commensal bacterium in the gut by showing that the supernatant of F. prausnitzii inhibits NF-κB activation in a human IEC line and suppresses the production of pro-inflammatory cytokines both in vitro and in a mouse colitis model.