Recent observations demonstrated that intra-cerebroventricular transplantation of MSCs in mice with severe experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis, can induce the formation of cellular masses with collagen/fibronectin deposition in the brain parenchyma (Grigoriadis et al. 2011). This evidence concerns the gene FN1 and experimental autoimmune encephalomyelitis.