For instance, this fibulin acts as an anti-angiogenic factor in nasopharyngeal carcinoma [23]; FBLN2, the human gene coding for fibulin-2, is found epigenetically silenced in B cell acute lymphoblastic leukemia [24]; and loss of fibulin-2 expression facilitates tumor progression in breast cancer cells [25]. This evidence concerns the gene FBLN2 and B-cell acute lymphoblastic leukemia.