Because AID contributes to tumorigenesis, imatinib resistance, clonal evolution, and immune evasion in various hematopoietic malignancies [6, 10, 50], our results provide a novel molecular basis for a new indication of 5-aza-CdR in treating AID-positive hematopoietic cancers. Here, AICDA is linked to hematopoietic and lymphoid cell neoplasm.