PTGS2 and infection: Accordingly, increase of LD numbers produced during infection is related to the generation of eicosanoids, where LDs have been shown as sites of compartmentalization of eicosanoid-forming enzymes and domains involved in the mechanisms of enhanced eicosanoid production during inflammatory and infectious conditions[12,17,22] such as prostaglandin E2 (PGE2), a product of cyclooxygenase-2 (COX-2) gene induction[23].