A total of 545 cases of breast cancer were identified with molecular subtypes, including 202 cases (37.1%) of lumina A type (ERα+, PR+, Her-2-), 147 cases (27.0%) of luminal B type (ERα+, PR+, Her-2+), 95 cases (17.4%) of Her-2 over-expression type (ERα-, PR-, Her-2+) and 101 cases (18.5%) of basal like type (ERα-, PR-, Her-2-). The gene discussed is ESR1; the disease is breast cancer.