WWOX and Severe short stature: Moreover, there is considerable overlap of symptoms in our patients with those observed in Wwox murine models (Table 1): A spontaneous homozygous Wwox frameshift mutation (p.Leu371Thrfs*41) resulting in non-detectable protein underlies lethal dwarfism and epilepsy (lde) in lde/lde rats, suggesting an important role of WWOX for development and integrity of the nervous system [7].