Metronomic chemotherapy, although initially shown to inhibit angiogenesis and reduce the levels of some biological markers (e.g. VEGF) is now proven to modulate immune responses, by increasing the de novo generation of tumor-specific effector T-cells, re-sensitize pre-existing suppressed tumor-reactive T-, NK- and NKT-mediated responses and induce the maturation of dendritic cells [21,23]. The gene discussed is VEGFA; the disease is neoplasm.