MLH1 and cancer: While the MLH1 dependent decrease of SPTAN1 expression might be easily explainable by missing MLH1 protein stabilization and has been shown for other MLH1 partner proteins before [26,27], the explanation for reduced SPTAN1 mRNA levels in four of six cancer cell lines detectable after siRNA-specific down knocking of MLH1 using two different siRNAs seems to be more difficult.