BBR inhibits melanoma cell invasion and metastasis by inhibition of COX-2, PGE2 and PGE2 receptors[17] and several other signaling molecules such as ERK1/2, NF-κB, ATF-2 and CREB which are involved in the transcriptional regulation of matrix metalloproteinase (MMP) gene expression[30]. The gene discussed is MAPK3; the disease is melanoma.