Although no other studies examined the effect of wine on Akt in cancer cells, we observed inhibition of basal Akt phosphorylation with 2.5 and 5 μM resveratrol in human PC3 and 22RV1 prostate cancer cells[17] and other studies in breast[35] and uterine[36] cancer cells showed similar results with 100 μM resveratrol. This evidence concerns the gene AKT1 and cancer.